What are benzodiazepines?
Benzodiazepines are medications that enhance the action of the inhibitory neurotransmitter GABA at GABA-A receptors. They are prescribed for selected conditions, including certain anxiety and seizure disorders, and may cause sedation and impaired coordination.
Dependence is not the same as addiction
Physical dependence means the body has adapted to a substance and may experience withdrawal after reduction or discontinuation. A substance use disorder involves a different pattern of impaired control and harmful use; the two can coexist, but are not identical.
Tolerance and adaptation
Effects may change with repeated exposure. Withdrawal risk varies with the drug, duration, dose, individual history, other substances, and health conditions.
Risks and interactions
Combining benzodiazepines with opioids, alcohol, or other sedating drugs increases risks including respiratory depression and overdose. Discuss all medications and substances with a clinician.
Explore drug profiles
Our library includes commonly prescribed benzodiazepines and a separate evidence-limited novel benzodiazepine index.
Further reading
External sources for additional context; they do not replace medical care.